| First Author | Christianson SW | Year | 1996 |
| Journal | Cell Immunol | Volume | 171 |
| Issue | 2 | Pages | 186-99 |
| PubMed ID | 8806787 | Mgi Jnum | J:34814 |
| Mgi Id | MGI:82280 | Doi | 10.1006/cimm.1996.0193 |
| Citation | Christianson SW, et al. (1996) Role of natural killer cells on engraftment of human lymphoid cells and on metastasis of human T-lymphoblastoid leukemia cells in C57BL/6J-scid mice and in C57BL/6J-scid bg mice. Cell Immunol 171(2):186-99 |
| abstractText | The severe combined immunodeficiency (scid) mutation was backcrossed onto the C57BL/6J strain background in order to study the role of natural killer (NK) cells in rejection of normal and malignant human lymphohematopoietic cells. C57BL/6J-scid/scid mice showed severe loss of mature T and B cells accompanied by increased percentages of NK1.1+ cells and myeloid cells. Although little or no serum immunoglobulin was detectable prior to 2 months of age, all mice tested had circulating immunoglobulin by 7.5 months of age. C57BL/6J-scid/scid mice had markedly elevated levels of both hemolytic complement activity and NK cell activity |
