| Primary Identifier | MGI:1855979 | Allele Type | Spontaneous |
| Gene | Tyr | Inheritance Mode | Semidominant |
| Strain of Origin | (DBA/2 x AKR/J)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Melanin granules of the retina are indistinguishable from those of chinchilla or of wild-type homozygotes (J:5001). Pigment synthesis in himalayan mice is temperature-sensitive; pigment develops in growing hairs of mice housed at 15oC but not in those housed at 30oC (J:6275). In explanation of this effect, it has been shown that tyrosinase in these mice is heat-labile (J:12173), being maximally active at well below body temperature. Tyrosinase of Tyrch homozygotes is strongly bound by an inhibitor at 37oC but not at lower temperatures (J:6508). |
| molecularNote | The mutation in the himalayan allele was found to be an A-to-G point mutation at coding nucleotide 1259 that results in an amino acid change at position 420 from histidine to arginine (p.H420R). |
