| First Author | Lim K | Year | 2015 |
| Journal | Science | Volume | 349 |
| Issue | 6252 | Pages | aaa4352 |
| PubMed ID | 26339033 | Mgi Jnum | J:226499 |
| Mgi Id | MGI:5697599 | Doi | 10.1126/science.aaa4352 |
| Citation | Lim K, et al. (2015) Neutrophil trails guide influenza-specific CD8(+) T cells in the airways. Science 349(6252):aaa4352 |
| abstractText | During viral infections, chemokines guide activated effector T cells to infection sites. However, the cells responsible for producing these chemokines and how such chemokines recruit T cells are unknown. Here, we show that the early recruitment of neutrophils into influenza-infected trachea is essential for CD8(+) T cell-mediated immune protection in mice. We observed that migrating neutrophils leave behind long-lasting trails that are enriched in the chemokine CXCL12. Experiments with granulocyte-specific CXCL12 conditionally depleted mice and a CXCR4 antagonist revealed that CXCL12 derived from neutrophil trails is critical for virus-specific CD8(+) T cell recruitment and effector functions. Collectively, these results suggest that neutrophils deposit long-lasting, chemokine-containing trails, which may provide both chemotactic and haptotactic cues for efficient CD8(+) T cell migration and localization in influenza-infected tissues. |
