| First Author | DeMars R | Year | 1976 |
| Journal | Proc Natl Acad Sci U S A | Volume | 73 |
| Issue | 5 | Pages | 1693-7 |
| PubMed ID | 5727 | Mgi Jnum | J:5653 |
| Mgi Id | MGI:54130 | Doi | 10.1073/pnas.73.5.1693 |
| Citation | DeMars R, et al. (1976) Abnormal ornithine carbamoyltransferase in mice having the sparse-fur mutation. Proc Natl Acad Sci U S A 73(5):1693-7 |
| abstractText | Mice with the X-chromosomal sparse-fur (spf) mutation frequently have urinary bladder stones composed mostly of orotic acid, which was identified by the following criteria: ultraviolet and infrared absorption, spectra, chromatographic behavior, melting point, and reactivity in a specific color test. This clue led to the discovery that spf-bearing mice have an abnormal form of liver ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase, EC 2.1.3.3). Normal ornithine carbamoyltransferase has maximum activity at pH 7.6-8.0 and 80% of maximum activity at pH 10.0. |
