| First Author | Lyon MF | Year | 1984 |
| Journal | Cell | Volume | 37 |
| Issue | 2 | Pages | 621-8 |
| PubMed ID | 6722884 | Mgi Jnum | J:7443 |
| Mgi Id | MGI:55913 | Doi | 10.1016/0092-8674(84)90393-3 |
| Citation | Lyon MF (1984) Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell 37(2):621-8 |
| abstractText | Transmission ratios of male mice heterozygous for various combinations of partial t-haplotypes provide evidence in support of a model for the genetic basis of ratio distortion, involving two or more distorter genes acting on a responder locus. The t form of the responder locus, Tcr, in the medial part of the haplotype, must be present and heterozygous for distortion to occur. When the responder alone is present, as in t low haplotypes, the chromosome carrying it is transmitted in a low ratio (less than 50%). The t forms of the distorter loci act additively, in cis or trans, to raise the transmission of whichever chromosome carries Tcr. Identified distorter loci are Tcd-1, in the proximal part of the haplotype, Tcd-2, distal to Tcr, and probably Tcd-3, lying between Tcr and Tcd-2. In the absence of Tcr the distorters are transmitted normally. The system is compared with the SD system of Drosophila. |
