| Primary Identifier | MGI:1856185 | Allele Type | Radiation induced |
| Gene | T | Inheritance Mode | Semidominant |
| Strain of Origin | (C3H/HeH x 101/H)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Tc, curtailed, semidominant. Found among offspring from a cross between a multiple recessive testing stock, T stock, and a pup from an irradiated C3H/HeH female that had been impregnated by a 101/H male. Heterozygotes have complete or near-complete absence of the tail, absence of the odontoid process of the axis, absence of the nucleus pulposi of the intervertebral discs, a tendency for rib and vertebral fusions, and a slight decrease in average number of presacral vertebrae. They occasionally show paralysis of the hindlimbs and atresia ani. Homozygotes die at the same time as T/T embryos and are similar to them but more severely affected. Tc/T embryos are variable and intermediate between T/T and T c/T c (J:5003). |
| molecularNote | Southern analysis of genomic DNA showed that this allele does not comprise a deletion of flanking loci, D17Leh119II and D17RP17, as found for alleles Thp and TOrl. Sequencing genomic DNA from the open reading frame revealed a 19 bp deletion of GCACACGGTCTCAGCTGCC predicted to result in a protein truncated at the carboxyl-terminal end. |
