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Publication : Residual androgen binding in testicular feminization (TFM).

First Author  Fox TO Year  1983
Journal  J Steroid Biochem Volume  19
Issue  1B Pages  577-81
PubMed ID  6887886 Mgi Jnum  J:7179
Mgi Id  MGI:55650 Doi  10.1016/0022-4731(83)90220-0
Citation  Fox TO, et al. (1983) Residual androgen binding in testicular feminization (TFM). J Steroid Biochem 19(1B):577-81
abstractText  Most mutants with genetic androgen-resistance possess some level of androgen binding which exhibits properties of receptors. The present studies aim to determine whether the androgen binding activities in mutants are, or are related to, receptors. This binding portion is termed residual androgen receptors. We have examined several androgen-resistance mutants with testicular feminization (TFM). Putative androgen receptors from mice, rats, and humans with TFM have been compared, and at least three different types of residual receptors have been observed. They are discussed in relation to possible receptor defects and to differences in the nature of androgen-resistance associated with each of them.
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