| First Author | Nahm SS | Year | 2003 |
| Journal | Neurobiol Dis | Volume | 14 |
| Issue | 2 | Pages | 157-65 |
| PubMed ID | 14572439 | Mgi Jnum | J:126207 |
| Mgi Id | MGI:3760710 | Doi | 10.1016/s0969-9961(03)00106-2 |
| Citation | Nahm SS, et al. (2003) Insulin-like growth factor-I improves cerebellar dysfunction but does not prevent cerebellar neurodegeneration in the calcium channel mutant mouse, leaner. Neurobiol Dis 14(2):157-65 |
| abstractText | The effects of insulin-like growth factor-I (IGF-I) on cerebellar dysfunction and neurodegeneration were investigated in leaner mice, which exhibit cerebellar ataxia and neurodegeneration related to P/Q-type calcium channel mutations. Leaner mice showed significantly reduced serum and cerebellar IGF-I concentrations compared to wild-type mice at postnatal day 30. Behavioral assessment of leaner mice injected with IGF-I subcutaneously for 4 weeks showed partially improved cerebellar function. Histological analysis of IGF-I treated leaner cerebella showed no difference in the number of dying Purkinje cells compared to control leaner cerebella. These results further support potential use of IGF-I as a therapeutic aid for cerebellar ataxia related to calcium channel mutations. Nonetheless, IGF-I administration does not rescue dying cerebellar neurons, which suggests that the beneficial effects of IGF-I may have been achieved through surviving cerebellar neurons. |
