| First Author | Fujita Y | Year | 2012 |
| Journal | Cell Immunol | Volume | 273 |
| Issue | 1 | Pages | 52-8 |
| PubMed ID | 22196379 | Mgi Jnum | J:181367 |
| Mgi Id | MGI:5311091 | Doi | 10.1016/j.cellimm.2011.11.007 |
| Citation | Fujita Y, et al. (2012) Prevention of fasting-mediated bone marrow atrophy by leptin administration. Cell Immunol 273(1):52-8 |
| abstractText | Leptin is an adipokine that regulates body weight. In the current study, we demonstrate that continuous injection of leptin prevents the lymphocyte reduction observed in fasted mice, especially the immature B cell populations in the bone marrow. Although leptin administration reduced apoptotic cells in the bone marrow of fasted mice, it did not prevent glucocorticoid-mediated apoptosis in vitro. Bone marrow atrophy has also been shown in the leptin receptor-deficient db/db mice. In order to investigate the mechanisms underlying these processes, we transplanted bone marrow cells from db/db or control (+m/+m) mice into C.B-17/lcr-scid/scid mice. We found that the spleen and bone marrow B cell populations were completely reconstituted when db/db and +m/+m cells were transplanted into scid mice. Our findings suggest that direct interactions between leptin and bone marrow cells are not essential for the development of B cells in a metabologically normal environment. |
