| First Author | Moritani M | Year | 2006 |
| Journal | Genomics | Volume | 88 |
| Issue | 6 | Pages | 719-730 |
| PubMed ID | 16919419 | Mgi Jnum | J:116038 |
| Mgi Id | MGI:3692737 | Doi | 10.1016/j.ygeno.2006.07.002 |
| Citation | Moritani M, et al. (2006) Identification of diabetes susceptibility loci in db mice by combined quantitative trait loci analysis and haplotype mapping. Genomics 88(6):719-30 |
| abstractText | To identify the disease-susceptibility genes of type 2 diabetes, we performed quantitative trait loci (QTL) analysis in F(2) populations generated from a BKS.Cg-m+/+Lepr(db) and C3H/HeJ intercross, taking advantage of genetically determined obesity and diabetes traits associated with the db gene. A genome-wide scan in the F(2) populations divided by sex and db genotypes identified 14 QTLs in total and 3 major QTLs on chromosome (Chr) 3 (LOD 5.78) for fat pad weight, Chr 15 (LOD 6.64) for body weight, and Chr 16 (LOD 8.15) for blood glucose concentrations. A linear-model-based genome scan using interactive covariates allowed us to consider sex- or sex-by db-specific effects of each locus. For the most significant QTL on Chr 16, the high-resolution haplotype comparison between BKS and C3H strains reduced the critical QTL interval from 20 to 4.6 Mb by excluding shared haplotype regions and identified 11 nonsynonymous single-nucleotide polymorphisms in six candidate genes. |
