| First Author | Zhang Y | Year | 2020 |
| Journal | Phytother Res | Volume | 34 |
| Issue | 12 | Pages | 3168-3179 |
| PubMed ID | 32592532 | Mgi Jnum | J:360195 |
| Mgi Id | MGI:7664702 | Doi | 10.1002/ptr.6747 |
| Citation | Zhang Y, et al. (2020) Sophoricoside is a selective LXRbeta antagonist with potent therapeutic effects on hepatic steatosis of mice. Phytother Res 34(12):3168-3179 |
| abstractText | Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease characterized by the accumulation of triglycerides and associated with obesity, hyperlipidemia and insulin resistance. Currently, there is no therapy for NAFLD. Emerging evidences suggest that the inhibition of liver X receptor (LXR) activity may be a potential therapy for hepatic steatosis. Here, we identified that sophoricoside is a selective antagonist of LXRbeta. Sophoricoside protected against obesity and glucose tolerance, and inhibited lipid accumulation in the liver of high-fat diet-induced obesity (DIO) mice and methionine and choline-deficient diet-induced nonalcoholic steatohepatitis mice. Furthermore, sophoricoside inhibited malondialdehyde, and increased superoxide dismutase and glutathione in the liver of the mice. In HepG2 cells, pretreatment with sophoricoside rescued GSH concentration decrease induced by H(2) O(2) treatment. Our data suggest that sophoricoside is a novel LXRbeta selective antagonist and may improve glucose and lipid dysfunction, and attenuate lipid accumulation in the liver of DIO mice via anti-oxidant properties, which may be developed as a therapy for NAFLD. |
