| First Author | Asahara S | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 381 |
| Issue | 3 | Pages | 367-71 |
| PubMed ID | 19309774 | Mgi Jnum | J:147192 |
| Mgi Id | MGI:3839679 | Doi | 10.1016/j.bbrc.2009.02.047 |
| Citation | Asahara S, et al. (2009) Increased ribosomal biogenesis induces pancreatic beta cell failure in mice model of type 2 diabetes. Biochem Biophys Res Commun 381(3):367-71 |
| abstractText | AIM: To study the changes in gene expression by pancreatic beta cells under insulin resistance conditions. METHOD: An exhaustive gene expression analysis was performed, using isolated pancreatic islets of obese diabetic model Lepr(-/-) mice. Overexpression of cyclin D2 was induced in cells from the pancreatic beta cell line, namely, INS-1. RESULTS: Through a gene expression analysis using islets isolated from db/db mice, we found a significant increase in the expression of ribosome-related molecules. In addition, increased expression of cyclin D2 was found at certain protein levels. As INS-1 cells were induced to overexpress cyclin D2, we found an increase in the expression of ribosome-related molecules. Concurrently, an increase in the expression of endoplasmic reticulum stress (ER stress)-related molecules was also found. CONCLUSION: In cases of pancreatic beta cell hyperplasia associated with insulin resistance, ribosomal biogenesis is increased, and ER stress is induced. |
