| First Author | Tulsiani DR | Year | 1979 |
| Journal | Diabetes | Volume | 28 |
| Issue | 9 | Pages | 793-8 |
| PubMed ID | 38160 | Mgi Jnum | J:323240 |
| Mgi Id | MGI:7262842 | Doi | 10.2337/diab.28.9.793 |
| Citation | Tulsiani DR, et al. (1979) Studies on dehydrogenases of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Diabetes 28(9):793-8 |
| abstractText | In view of reports that accessory pathways of glucose oxidation are enhanced in the diabetic state, we have determined the levels of key enzymes of the glucuronate-xylulose cycle in the livers of diabetic mice and rats. Genetically diabetic mice (db/db) were found to have increased levels of two NADP-linked enzymes of this cycle [NADP-xylitol dehydrogenase and NADP-L-hexonate dehydrogenase (aldehyde reductase II)], whereas other NAD- and NADP-linked dehydrogenase activities of the pathway were not changed. On the other hand, the livers of streptozotocin-diabetic mice and rats showed normal levels of all these enzymes. In the course of this study, evidence was obtained for the presence in db/db mouse liver of low molecular weight material inhibitory for glucose 6-phosphate dehydrogenase. The use of these animal models in diabetes research is briefly discussed. |
