| First Author | Feng X | Year | 2019 |
| Journal | Nat Med | Volume | 25 |
| Issue | 4 | Pages | 575-582 |
| PubMed ID | 30833749 | Mgi Jnum | J:294697 |
| Mgi Id | MGI:6445341 | Doi | 10.1038/s41591-019-0358-x |
| Citation | Feng X, et al. (2019) IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects. Nat Med 25(4):575-582 |
| abstractText | Celastrol, a pentacyclic triterpene, is the most potent antiobesity agent that has been reported thus far(1). The mechanism of celastrol's leptin-sensitizing and antiobesity effects has not yet been elucidated. In this study, we identified interleukin-1 receptor 1 (IL1R1) as a mediator of celastrol's action by using temporally resolved analysis of the hypothalamic transcriptome in celastrol-treated DIO, lean, and db/db mice. We demonstrate that IL1R1-deficient mice are completely resistant to the effects of celastrol in leptin sensitization and treatment of obesity, diabetes, and nonalcoholic steatohepatitis. Thus, we conclude that IL1R1 is a gatekeeper for celastrol's metabolic actions. |
