| First Author | Krieger K | Year | 2018 |
| Journal | J Invest Dermatol | Volume | 138 |
| Issue | 2 | Pages | 256-264 |
| PubMed ID | 28942365 | Mgi Jnum | J:277028 |
| Mgi Id | MGI:6296413 | Doi | 10.1016/j.jid.2017.08.042 |
| Citation | Krieger K, et al. (2018) NF-kappaB Participates in Mouse Hair Cycle Control and Plays Distinct Roles in the Various Pelage Hair Follicle Types. J Invest Dermatol 138(2):256-264 |
| abstractText | The transcription factor NF-kappaB controls key features of hair follicle (HF) development, but the role of NF-kappaB in adult HF cycle regulation remains obscure. Using NF-kappaB reporter mouse models, strong NF-kappaB activity was detected in the secondary hair germ of late telogen and early anagen HFs, suggesting a potential role for NF-kappaB in HF stem/progenitor cell activation during anagen induction. At mid-anagen, NF-kappaB activity was observed in the inner root sheath and unilaterally clustered in the HF matrix, which indicates that NF-kappaB activity is also involved in hair fiber morphogenesis during HF cycling. A mouse model with inducible NF-kappaB suppression in the epithelium revealed pelage hair-type-dependent functions of NF-kappaB in cycling HFs. NF-kappaB participates in telogen-anagen transition in awl and zigzag HFs, and is required for zigzag hair bending and guard HF cycling. Interestingly, zigzag hair shaft bending depends on noncanonical NF-kappaB signaling, which previously has only been associated with lymphoid cell biology. Furthermore, loss of guard HF cycling suggests that in this particular hair type, NF-kappaB is indispensable for stem cell activation, maintenance, and/or growth. |
