| First Author | Kothary R | Year | 1988 |
| Journal | Nature | Volume | 335 |
| Issue | 6189 | Pages | 435-7 |
| PubMed ID | 3138544 | Mgi Jnum | J:17844 |
| Mgi Id | MGI:65870 | Doi | 10.1038/335435a0 |
| Citation | Kothary R, et al. (1988) A transgene containing lacZ inserted into the dystonia locus is expressed in neural tube. Nature 335(6189):435-7 |
| abstractText | The site of integration of transgenes in the host genome can affect levels of expression and occasionally confer ectopic patterns of expression on otherwise tissue-specific genes. We describe here a line of mice in which an hsp68-lacZ transgene is expressed in unstressed developing neural tissue and where the transgene insertion has caused a mutation of a neural tissue-specific gene, dystonia musculorum (dt). This coincidence suggests that expression of the hsp68-lacZ construct may be controlled directly by cis-acting regulatory sequences that normally control the developmental expression of the dt gene. Such constructs may serve as useful tools for identifying new tissue-specific enhancers and their associated genes. |
