| Primary Identifier | MGI:1856025 | Allele Type | Spontaneous |
| Gene | Pou1f1 | Inheritance Mode | Recessive |
| Strain of Origin | C3H/HeJ | Is Recombinase | false |
| Is Wild Type | false |
| description | This remutation of the Snell dwarf gene occurred in the C3H/HeJ strain (J:6342). Mutant mice homozygous for Pit1dw-J, like homozygotes for Pit1dw, lack PIT1 protein activity and have no lactotrophs, thyrotrophs, or somatotrophs (J:10774). |
| molecularNote | The mutation was characterized by Southern blot as either a chromosomal inversion or an insertion of greater than 4kb in the gene. PCR analysis revealed that most of exon 3 is intact, but the exact break points are not established. |
