| First Author | Katoh H | Year | 1989 |
| Journal | Mouse News Lett | Volume | 84 |
| Pages | 94 | Mgi Jnum | J:14256 |
| Mgi Id | MGI:62428 | Citation | Katoh H (1989) Hotfoot (hoJic). Mouse News Lett 84:94 |
| abstractText | Full text of MNL contribution: Research News: a. Hotfoot (hoJic). We found two male mice with creeping-like walking motion in a litter (one female and four males) of the Bl0.PL(73NS)/Sn strain (abbreviated 73NS) in 1983. Family studies showed that this mutant was determined by a single autosomal recessive gene. In order to carry out linkage analysis, mating experiments were performed with the DBA/2 strain which has different genotypes from 73NS. (DBA/2 female x 73NS mutant male) Fl female was mated with a 73NS mutant male. Backcross progeny were typed for fifteen markers as follows: Idh-l (chr. 1), Pep-3 (1), Car-2 (3), Mup-1 (4), Gpd-1 (4), Pgm-1 (5), Ly-2 (6), Gpi-1 (7), Hbb (7), Es-1 (8), Es-3 (11), Hba (11), Igh-C (12), H-2 (17), and Ly-l (19). At the same time, phenotypes (normal and abnormal) of walking motion were recorded. The linkage test showed that the mutant gene is located on chromosome 6, and linked to the Ly-2 locus. Only one out of 31 backcross mice was a recombinant. Therefore, the distance between the mutant gene and the Ly-2 locus was calculated as 3.2 cM. Not only the linkage data but also the walking motion of the mutant mouse suggest that the mutant mouse in this report is the same as the hotfoot mouse which was reported from the Jackson Laboratory (Dickie, M.M. 1966. Mouse News Lett. 34:30). The mutant gene reported in this paper was named honJic (hotfoot Jic(CIEA)). (H. Katoh). |
