| First Author | Lee JY | Year | 2021 |
| Journal | Sci Adv | Volume | 7 |
| Issue | 51 | Pages | eabj9111 |
| PubMed ID | 34910517 | Mgi Jnum | J:317034 |
| Mgi Id | MGI:6842842 | Doi | 10.1126/sciadv.abj9111 |
| Citation | Lee JY, et al. (2021) Misexpression of genes lacking CpG islands drives degenerative changes during aging. Sci Adv 7(51):eabj9111 |
| abstractText | Cellular aging is characterized by disruption of the nuclear lamina and its associated heterochromatin. How these structural changes within the nucleus contribute to age-related degeneration of the organism is unclear. Genes lacking CpG islands (CGI(-) genes) generally associate with heterochromatin when they are inactive. Here, we show that the expression of these genes is globally activated in aged cells and tissues. This CGI(-) gene misexpression is a common feature of normal and pathological aging in mice and humans. We report evidence that CGI(-) gene up-regulation is directly responsible for age-related physiological deterioration, notably for increased secretion of inflammatory mediators. |
