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Publication : TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1.

First Author  Johnson KG Year  1999
Journal  J Immunol Volume  162
Issue  7 Pages  3802-13
PubMed ID  10201897 Mgi Jnum  J:53576
Mgi Id  MGI:1332950 Doi  10.4049/jimmunol.162.7.3802
Citation  Johnson KG, et al. (1999) TCR signaling thresholds regulating T cell development and activation are dependent upon SHP-1. J Immunol 162(7):3802-13
abstractText  An examination of thymocytes and peripheral T cells from SHP-1-deficient motheaten mice possessing a transgenic MHC class I-restricted TCR has implicated SHP-1 in regulating TCR signaling thresholds at three checkpoints in T cell development and activation. First, in the population of CD4-CD8- double negative thymocytes, SHP-1 appears capable of regulating signals from TCR complexes that control the maturation and proliferation of double negative thymocytes. Second, the loss of SHP-1 increased the number of CD4+CD8+ double positive thymocytes capable of maturing as TCRhigh single positive thymocytes. Third, the loss of SHP-1 altered the basal level of activation of naive lymph node T cells. Accordingly, SHP-1-deficient lymph node T cells bearing the transgenic TCR demonstrated a hyperresponsiveness to stimulation with cognate peptide. However, the loss of SHP-1 did not alter the cytolytic ability of mature effector cytotoxic T lymphocytes. Together these results suggest that SHP-1 contributes to establishing thresholds for TCR signaling in thymocytes and naive peripheral T cells.
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