| First Author | Liang B | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 9 | Pages | 5916-26 |
| PubMed ID | 18424711 | Mgi Jnum | J:134316 |
| Mgi Id | MGI:3785317 | Doi | 10.4049/jimmunol.180.9.5916 |
| Citation | Liang B, et al. (2008) Regulatory T Cells Inhibit Dendritic Cells by Lymphocyte Activation Gene-3 Engagement of MHC Class II. J Immunol 180(9):5916-26 |
| abstractText | Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that during Treg:DC interactions, LAG-3 engagement with MHC class II inhibits DC activation. MHC II cross-linking by agonistic Abs induces an ITAM-mediated inhibitory signaling pathway, involving FcgammaRgamma and ERK-mediated recruitment of SHP-1 that suppresses dendritic cell maturation and immunostimulatory capacity. These data reveal a novel ITAM-mediated inhibitory signaling pathway in DCs triggered by MHC II engagement of LAG-3, providing a molecular mechanism in which regulatory T cells may suppress via modulating DC function. |
