| First Author | Forget G | Year | 2001 |
| Journal | Eur J Immunol | Volume | 31 |
| Issue | 11 | Pages | 3185-96 |
| PubMed ID | 11745335 | Mgi Jnum | J:72585 |
| Mgi Id | MGI:2153279 | Doi | 10.1002/1521-4141(200111)31:11<3185::aid-immu3185>3.0.co;2-j |
| Citation | Forget G, et al. (2001) Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis. Eur J Immunol 31(11):3185-96 |
| abstractText | Activation of host phosphotyrosine phosphatase SHP-1 by Leishmania and its subsequent impact on tyrosine phosphorylation-based signaling cascades were shown to represent an important mechanism whereby this pathogen may alter host cell functions. Herein, we report that Leishmania-induced macrophage SHP-1 activity is necessary for its survival within phagocytes through the attenuation of nitric oxide-dependent and -independent microbicidal mechanisms. In vivo, Leishmania major infection, which footpad inflammation is mostly undetectable in SHP-1-deficient viable motheaten mice, was accompanied by increased inducible nitric oxide synthase and activation of neutrophils. These enhanced cellular activities were paralleled by a marked activation of signaling events usually negatively regulated by SHP-1. Overall, this study firmly establishes that modulation of the signaling terminator SHP-1 by Leishmania is essential for its installment and propagation. |
