| First Author | Beechey CV | Year | 1983 |
| Journal | Mouse News Lett | Volume | 68 |
| Pages | 70 | Mgi Jnum | J:13934 |
| Mgi Id | MGI:62112 | Citation | Beechey CV, et al. (1983) Two new W mutations. Mouse News Lett 68:70 |
| abstractText | Full text of MNL contribution: 9. Two new W mutations. (i) W<26H> arose in an Rw go bf/+ go bf stock, in which a female had a broad band of depigmentation in the trunk region rather than in the expected rump region, thus looking like a high-grade Ph or a W<sh> heterozygote. Crossed with Ph or with Rw it gave viable and fertile compounds with pigmentation only on the head. Crossed with W<v> it gave viable and fertile black-eyed white progeny, with occasional slight ear pigmentation. Homozygotes for the new mutation are also viable and fertile (in the male, females still under test ), with no obvious signs of anaemia. They are black-eyed white, apart from some signs of pigmentation on ears and snout. Thus they resemble W<sh> homozygotes, but fertile W<26H>W<sh> compounds have much more pigmentation on the head than either homozygote, which suggests that these are different alleles. (ii) W<27H> arose in the CBA/H strain and is being maintained on the same inbred background. Heterozygotes have much white-spotting on the head and trunk and in this respect resemble a previous W mutation in CBA reported by us in 1974 (MNL 51: 20) and thought similar to W<b>. Homozygotes are very anaemic, surviving for a few days at most. Compounds with W<v> are sterile black-eyed white, with reduced viability, while compounds with Ph are also black-eyed white, except for a little ear pigmentation. (Beechey and Searle) |
