| First Author | Meulenbroeks C | Year | 2015 |
| Journal | J Invest Dermatol | Volume | 135 |
| Issue | 1 | Pages | 222-228 |
| PubMed ID | 25089660 | Mgi Jnum | J:324486 |
| Mgi Id | MGI:6884052 | Doi | 10.1038/jid.2014.329 |
| Citation | Meulenbroeks C, et al. (2015) Basophil-derived amphiregulin is essential for UVB irradiation-induced immune suppression. J Invest Dermatol 135(1):222-228 |
| abstractText | UVB irradiation (290-320 nm) is used to treat skin diseases like psoriasis and atopic dermatitis, and is known to suppress contact hypersensitivity (CHS) reactions in mouse models. Regulatory T cells (Treg cells) have been shown to be responsible for this UVB-induced suppression of CHS. The epidermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in different disease models, it was shown that mast cell-derived AREG is essential for optimal Treg cell function in vivo. Here we determined whether AREG has a role in UVB-induced, Treg cell-mediated suppression of CHS reactions in the skin. Our data show that AREG is essential for UVB-induced CHS suppression. In contrast to the general assumption, however, mast cells were dispensable for UVB-induced immune suppression, whereas basophil-derived AREG was essential. These data reveal, to our knowledge, a previously unreported function for basophils in the homeostasis of immune responses in the skin. Basophils thus fulfill a dual function: they contribute to the initiation of effective type 2 immune responses and, by enhancing the suppressive capacity of local Treg cell populations, also to local immune regulation in the skin. |
