| First Author | Mishra SK | Year | 2020 |
| Journal | Cell Rep | Volume | 31 |
| Issue | 1 | Pages | 107472 |
| PubMed ID | 32268102 | Mgi Jnum | J:301446 |
| Mgi Id | MGI:6489175 | Doi | 10.1016/j.celrep.2020.03.036 |
| Citation | Mishra SK, et al. (2020) Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch. Cell Rep 31(1):107472 |
| abstractText | Chronic allergic itch is a common symptom affecting millions of people and animals, but its pathogenesis is not fully explained. Herein, we show that periostin, abundantly expressed in the skin of patients with atopic dermatitis (AD), induces itch in mice, dogs, and monkeys. We identify the integrin alphaVbeta3 expressed on a subset of sensory neurons as the periostin receptor. Using pharmacological and genetic approaches, we inhibited the function of neuronal integrin alphaVbeta3, which significantly reduces periostin-induced itch in mice. Furthermore, we show that the cytokine TSLP, the application of AD-causing MC903 (calcipotriol), and house dust mites all induce periostin secretion. Finally, we establish that the JAK/STAT pathway is a key regulator of periostin secretion in keratinocytes. Altogether, our results identify a TSLP-periostin reciprocal activation loop that links the skin to the spinal cord via peripheral sensory neurons, and we characterize the non-canonical functional role of an integrin in itch. |
