| First Author | Hershko AY | Year | 2011 |
| Journal | Immunity | Volume | 35 |
| Issue | 4 | Pages | 562-71 |
| PubMed ID | 21982597 | Mgi Jnum | J:177651 |
| Mgi Id | MGI:5295791 | Doi | 10.1016/j.immuni.2011.07.013 |
| Citation | Hershko AY, et al. (2011) Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis. Immunity 35(4):562-71 |
| abstractText | The incidence of chronic allergic dermatitis is rapidly increasing. Regulatory control of this disease has not been adequately explored. Here we report that mast cell-derived interleukin-2 (IL-2) contributes to the suppression of chronic allergic dermatitis. Mice deficient in IL-2 production, or deficient in mast cells (Kit(W-sh/W-sh)), showed exacerbated dermatitis upon repeated oxazolone challenge when compared to their wild-type counterparts. Adoptive transfer of wild-type, but not Il2(-/-), mast cells into Kit(W-sh/W-sh) mice dampened the inflammatory response. During the course of disease, mast cell expansion occurred at the site of inflammation and also in the spleen, where production of IL-2 by mast cells was markedly enhanced. In the absence of mast cell IL-2 production, the ratio of activated to regulatory T cells at the site of inflammation was increased. Thus, MC-derived IL-2 contributes to the maintenance of suppression in chronic allergic skin inflammation. |
