| First Author | Nakamura T | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 7514 | PubMed ID | 26159556 |
| Mgi Jnum | J:224362 | Mgi Id | MGI:5662129 |
| Doi | 10.1038/ncomms8514 | Citation | Nakamura T, et al. (2015) PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun 6:7514 |
| abstractText | Prostaglandin D2 (PGD2) is a major prostanoid secreted mainly by mast cells. Although PGD2 has been identified as a modulator of allergic inflammation, its precise role remains unclear. Here we investigate the role of PGD2 in food allergy. Oral administration of ovalbumin induces allergic responses in sensitized wild-type (WT) mice. Systemic gene deficiency of haematopoietic PGD synthase (H-PGDS(-/-)) exacerbates all of the manifestations accompanying severe mast cell hyperplasia in the intestine. Morphological studies show that c-kit/FcvarepsilonRI-positive WT mast cells strongly express H-PGDS. Transplantation of H-PGDS(-/-) mast cells also aggravates ovalbumin-induced mast cell hyperplasia and allergic symptoms in mast cell null mice. H-PGDS deficiency accelerates the production of SDF-1alpha and the activity of MMP-9 in the antigen-stimulated intestine. SDF-1alpha receptor blockade or MMP-9 inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS(-/-). Thus, PGD2 deficiency results in food antigen-induced mast cell hyperplasia. |
