| First Author | Crosby JR | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 8 | Pages | 4050-4 |
| PubMed ID | 11937563 | Mgi Jnum | J:125656 |
| Mgi Id | MGI:3759371 | Doi | 10.4049/jimmunol.168.8.4050 |
| Citation | Crosby JR, et al. (2002) Early phase bronchoconstriction in the mouse requires allergen-specific IgG. J Immunol 168(8):4050-4 |
| abstractText | Allergen provocation of allergic asthma patients is often characterized by an initial period of bronchoconstriction, or early phase reaction (EPR), that leads to maximal airway narrowing within 15-30 min, followed by a recovery period returning airway function to baseline within 1-2 h. In this study, we used a defined OVA provocation model and mice deficient for specific leukocyte populations to investigate the cellular/molecular origins of the EPR. OVA-sensitized/challenged wild-type (C57BL/6J) mice displayed an EPR following OVA provocation. However, this response was absent in gene knockout animals deficient of either B or T cells. Moreover, transfer of OVA-specific IgG, but not IgE, before the OVA provocation, was capable of inducing the EPR in both strains of lymphocyte-deficient mice. Interestingly, an EPR was also observed in sensitized/challenged mast cell-deficient mice following an OVA provocation. These data show that the EPR in the mouse is an immunologically based pathophysiological response that requires allergen-specific IgG but occurs independent of mast cell activities. Thus, in the mouse the initial period of bronchoconstriction following allergen exposure may involve neither mast cells nor IgE-mediated events. |
