| First Author | Morii E | Year | 2004 |
| Journal | Blood | Volume | 104 |
| Issue | 6 | Pages | 1656-61 |
| PubMed ID | 15172970 | Mgi Jnum | J:92959 |
| Mgi Id | MGI:3055256 | Doi | 10.1182/blood-2004-01-0247 |
| Citation | Morii E, et al. (2004) Roles of MITF for development of mast cells in mice: effects on both precursors and tissue environments. Blood 104(6):1656-61 |
| abstractText | The mutant tg/tg mice, which do not express mi transcription factor (MITF), lack mast cells in most tissues. Since MITF is expressed in both mast cells and tissues where mast cells develop, there is a possibility that the tg/tg mice may show abnormalities in both mast cell precursors and tissue environments. We examined this possibility by bone marrow and skin transplantation. When bone marrow cells of tg/tg mice were transplanted to W/W(v) mice that possess normal tissue environment, mast cells did not develop in all tissues examined. The number of developing mast cells in the skin of W/W(v) mice was much lower when grafted to tg/tg recipients than when grafted to normal (+/+) recipients. These results indicated that mast cell precursors of tg/tg mice were defective. When bone marrow cells of +/+ mice were transplanted, the number of developing mast cells was significantly lower in examined tissues of tg/tg recipients than in those of W/W(v) recipients, suggesting that the tissue environment for mast cell development was defective in tg/tg mice. MITF appeared essential for the function of both mast cell precursors and tissue environments for their development. |
