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Publication : Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya.

First Author  Takahashi E Year  2009
Journal  Behav Brain Res Volume  204
Issue  1 Pages  241-5
PubMed ID  19467269 Mgi Jnum  J:151450
Mgi Id  MGI:4353876 Doi  10.1016/j.bbr.2009.05.020
Citation  Takahashi E, et al. (2009) Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res 204(1):241-5
abstractText  Aged heterozygous Rolling Nagoya mice carrying Cav2.1alpha1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1alpha1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances.
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