First Author | Takahashi E | Year | 2009 |
Journal | Behav Brain Res | Volume | 204 |
Issue | 1 | Pages | 241-5 |
PubMed ID | 19467269 | Mgi Jnum | J:151450 |
Mgi Id | MGI:4353876 | Doi | 10.1016/j.bbr.2009.05.020 |
Citation | Takahashi E, et al. (2009) Age-related spatial and nonspatial short-term memory in Cav2.1alpha1 mutant mice, Rolling Nagoya. Behav Brain Res 204(1):241-5 |
abstractText | Aged heterozygous Rolling Nagoya mice carrying Cav2.1alpha1 mutation show deficits with regard to spatial short-term memory using hippocampus-related object location test, but not with regard to nonspatial memory using perirhinal cortex-related object recognition test. In hippocampus, wild-type Cav2.1alpha1 mRNA exhibited lower expression and mutant-type expression was higher in aged heterozygous mice. In perirhinal cortex, there were no significantly different expressions. Alteration of age-dependent expressions of Cav2.1 channels differs in different regions with related effects on behavioral performances. |