| First Author | Walker DG | Year | 1975 |
| Journal | Science | Volume | 190 |
| Issue | 4216 | Pages | 785-7 |
| PubMed ID | 1198094 | Mgi Jnum | J:5599 |
| Mgi Id | MGI:54076 | Doi | 10.1126/science.1198094 |
| Citation | Walker DG (1975) Spleen cells transmit osteopetrosis in mice. Science 190(4216):785-7 |
| abstractText | Osteopetrosis was induced in lethally irradiated, normal mice of grey-lethal and microphthalmic stocks by cell infusions prepared from the spleens of osteopetrotic littermates. Failure of skeletal remodeling became evident within a few weeks after transplantation as calcified cartilage and bone accumulated excessively in the active metaphyses of the long bones. The massive lesions produced were extensively infiltrated with abnormal osteoclasts. |
