| First Author | Kataru RP | Year | 2011 |
| Journal | Immunity | Volume | 34 |
| Issue | 1 | Pages | 96-107 |
| PubMed ID | 21256057 | Mgi Jnum | J:168062 |
| Mgi Id | MGI:4881838 | Doi | 10.1016/j.immuni.2010.12.016 |
| Citation | Kataru RP, et al. (2011) T lymphocytes negatively regulate lymph node lymphatic vessel formation. Immunity 34(1):96-107 |
| abstractText | Lymph node lymphatic vessels (LNLVs) serve as a conduit to drain antigens from peripheral tissues to within the lymph nodes. LNLV density is known to be positively regulated by vascular endothelial growth factors secreted by B cells, macrophages, and dendritic cells (DCs). Here, we show that LNLV formation was negatively regulated by T cells. In both steady and inflammatory states, the density of LNLVs was increased in the absence of T cells but decreased when T cells were restored. Interferon-gamma secretion by T cells suppressed lymphatic-specific genes in lymphatic endothelial cells and consequently caused marked reduction in LNLV formation. When T cells were depleted, recruitment of antigen-carrying DCs to LNs was augmented, reflecting a compensatory mechanism for antigen presentation to T cells through increased LNLVs. Thus, T cells maintain the homeostatic balance of LNLV density through a negative paracrine action of interferon-gamma. |
