| First Author | Huang W | Year | 2013 |
| Journal | J Immunol | Volume | 190 |
| Issue | 6 | Pages | 2490-4 |
| PubMed ID | 23408840 | Mgi Jnum | J:193676 |
| Mgi Id | MGI:5469208 | Doi | 10.4049/jimmunol.1202988 |
| Citation | Huang W, et al. (2013) Cutting Edge: Innate Memory CD8+ T Cells Are Distinct from Homeostatic Expanded CD8+ T Cells and Rapidly Respond to Primary Antigenic Stimuli. J Immunol 190(6):2490-4 |
| abstractText | Innate memory phenotype (IMP) CD8 T cells are nonconventional alphabeta T cells exhibiting features of innate immune cells and are significantly increased in the absence of ITK. Their developmental path and function are not clear. In this study, we show hematopoietic MHC class I (MHCI)-dependent generation of Ag-specific IMP CD8 T cells using bone marrow chimeras. Wild-type bone marrow gives rise to IMP CD8 T cells in MHCI recipients, resembling those in Itk mice, but distinct from those derived via homeostatic proliferation, and independent of recipient thymus. In contrast, MHCI bone marrow does not lead to IMP CD8 T cells in wild-type recipients. OTI IMP CD8 T cells generated via this method exhibited enhanced early response to Ag without prior primary stimulation. Our findings suggest a method to generate Ag-specific "naive" CD8 IMP T cells, as well as demonstrate that they are not homeostatic proliferation cells and can respond promptly in an Ag-specific fashion. |
