| First Author | Lin L | Year | 2005 |
| Journal | J Immunol | Volume | 175 |
| Issue | 2 | Pages | 951-8 |
| PubMed ID | 16002694 | Mgi Jnum | J:100704 |
| Mgi Id | MGI:3589323 | Doi | 10.4049/jimmunol.175.2.951 |
| Citation | Lin L, et al. (2005) Restraint of B cell activation by Foxj1-mediated antagonism of NF-kappa B and IL-6. J Immunol 175(2):951-8 |
| abstractText | The forkhead transcription factor Foxj1 inhibits spontaneous autoimmunity, in part by antagonizing NF-kappaB activation in T cells. We demonstrate here that Foxj1 also inhibits humoral immune responses intrinsically in B cells; Foxj1 deficiency in B cells results in spontaneous and accentuated germinal center formation, associated with the development of pathogenic autoantibodies and accentuated responses to immunizations-all reflecting excessive activity of NF-kappaB and its target gene IL-6, and correlating with a requirement for Foxj1 to regulate the inhibitory NF-kappaB component IkappaBbeta. Thus, Foxj1 restrains B cell activation and the maturation of humoral responses, demonstrating a critical role for at least this forkhead transcription factor in the regulation of B lymphocyte homeostasis. |
