| First Author | Chen YF | Year | 2021 |
| Journal | Anticancer Res | Volume | 41 |
| Issue | 5 | Pages | 2321-2331 |
| PubMed ID | 33952457 | Mgi Jnum | J:336581 |
| Mgi Id | MGI:6717746 | Doi | 10.21873/anticanres.15007 |
| Citation | Chen YF, et al. (2021) Involvement of Galectin-1 Tumor Microenvironment in Radiosensitivity. Anticancer Res 41(5):2321-2331 |
| abstractText | BACKGROUND/AIM: The mechanisms of galectin-1 in radioresistance may not only involve intracellular but also extracellular effects because galectin-1 can be secreted into the extracellular matrix. We, therefore, aimed to investigate the role of the galectin-1 tumor microenvironment on radiosensitivity in a murine tumor model. MATERIALS AND METHODS: Wild-type or stable galectin-1-down-regulated cancer cells (melanoma (B16F10) and lung cancer (LLC1)) were injected (subcutaneous injection) into wild-type or knockout (galectin-1, B cells, and T cells) mice that were subject to 0 or 8 Gy irradiation. RESULTS: Galectin-1-down-regulated B16F10 cells showed increased radiosensitivity when injected into galectin-1 knockout mice. Interestingly, radioresistance of wild-type LCC1 tumors was noted when injected into galectin-1 and B cell knockout mice. However, radiosensitization was observed in T cell knockout mice with wild-type LCC1 cells. CONCLUSION: The role of endogenous galectin-1 in radioresistance exists in cases without extracellular galectin-1. Extracellular galectin-1 requires endogenous galectin-1 to radiosensitize tumors in mice. |
