| First Author | Lauwen MM | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 3 | Pages | 893-900 |
| PubMed ID | 18245492 | Mgi Jnum | J:131863 |
| Mgi Id | MGI:3774731 | Doi | 10.1158/0008-5472.CAN-07-3166 |
| Citation | Lauwen MM, et al. (2008) Self-tolerance does not restrict the CD4+ T-helper response against the p53 tumor antigen. Cancer Res 68(3):893-900 |
| abstractText | Tumorigenesis is frequently associated with mutation and overexpression of p53, which makes it an attractive target antigen for T cell-mediated immunotherapy of cancer. However, the magnitude and breadth of the p53-specific T-cell repertoire may be restricted due to the ubiquitous expression of wild-type p53 in normal somatic tissues. In view of the importance of the CD4+ T-helper cell responses in effective antitumor immunity, we have analyzed and compared the p53-specific reactivity of this T cell subset in p53+/+ and p53-/- C57Bl/6 mice. This response was found to be directed against the same three immunodominant epitopes in both mouse types. Fine-specificity, magnitude, and avidity were not affected by self-tolerance. Immunization of p53-/- and p53+/+ mice with synthetic peptide vaccines comprising the identified epitopes induced equal levels of Th1 immunity. Our findings imply that the p53-specific CD4+ T-cell repertoire is not restricted by self-tolerance and is fully available for the targeting of cancer. |
