| First Author | Jockusch H | Year | 1987 |
| Journal | Mouse News Lett | Volume | 77 |
| Pages | 111-112 | Mgi Jnum | J:17790 |
| Mgi Id | MGI:65817 | Citation | Jockusch H, et al. (1987) A cross involving "arrested development of righting response", adr, and "nude", nu. Mouse News Lett 77:111-112 |
| abstractText | Full text of MNL contribution: H. JOCKUSCH, K. BERTRAM: A cross involving "arrested development of righting response", adr, and "nude", nu. We have shown the allelism between adr and "myotonia" (formerly mto, now adrmto, Jockusch & Bertram, 1986, MNL 75, 19). Lack of linkage of adrmto with selected markers on chromosomes 1, 2, 3, 4, 7, 9, 15, 17 and 19 has been reported (Heller, A.H. et al., 1982, J. Neurosci. 2, 9124-933). We have performed a cross involving a marker on Chr. 11, nu (phenotypes in parentheses): nu/nu +/+ (NU +) x +/+ adr/+ (+ +). So far, 33 F2 animals have been derived from 5 litters, each with =1 ADR mouse, i.e. with nu/+ adr/+ parental Fl mice. The F2 animals were scored for their phenotypes: phenotype: NU ADR; found: 1; expected*: 2.1 phenotype: NU +; found: 2; expected*: 6.2 phenotype: + ADR; found: 8; expected*: 6.2 phenotype: + +; found: 22; expected*: 18.6 *assuming independent assortment This result is compatible with a lack of linkage between nu (Chr. 11) and adr, especially when the deficit in NU animals is taken into account. In addition, it shows that the thymeless condition of NU does not interfere with the ADR phenotype, i.e. this muscular disease cannot be due to a T-cell dependent autoimmune defect (cf. Jockusch, H., 1982, Exp. Neur. 391-396, on the MED mouse). |
