| Primary Identifier | MGI:1856148 | Allele Type | Spontaneous |
| Gene | Ednrb | Inheritance Mode | Recessive |
| Strain of Origin | old mutant of the mouse fancy | Is Recombinase | false |
| Is Wild Type | false |
| description | Also called piebald spotting. This is a very old mutation of the mouse fancy, and was described in the scientific literature as early as 1920 (J23183). Some piebalds in existing stocks may be of independent origin. |
| molecularNote | This mutation is allelic to a targeted mutation for this gene. Homozygous mice produce approximately 25% of the normal levels of transcript from this allele. RT-PCR analysis demonstrated that no alterations in the coding sequence would result in any alteration of the amino acid sequence. A 5.5 kb retrotransposon-like element is found in intron 1. About 75% of the mRNA produced is an aberrant 6.5 kb form lacking exons 2-6 but containing exon 1. The remaining 25% of the mRNA formed is of normal, 4.4 kb, size. |
