| First Author | Sun T | Year | 1998 |
| Journal | Mol Cell Neurosci | Volume | 12 |
| Issue | 4-5 | Pages | 228-39 |
| PubMed ID | 9828088 | Mgi Jnum | J:50974 |
| Mgi Id | MGI:1313099 | Doi | 10.1006/mcne.1998.0711 |
| Citation | Sun T, et al. (1998) Pax6 influences the time and site of origin of glial precursors in the ventral neural tube. Mol Cell Neurosci 12(4-5):228-39 |
| abstractText | Neuroepithelial precursors in the ventral ventricular zone (VZ) of the spinal cord generate motor neurons (MNs) and interneurons, and then a subset of precursors starts to produce oligodendrocyte progenitors (OLPs). We show that OLPs originate in the ventral-most part of the Pax6-positive VZ, which at earlier times generates somatic (Isl2/Lim3-positive) MNs. In Small eye (Pax6-deficient) mice, the origin of OLPs is shifted dorsally and both OLPs and Isl2/Lim3 MNs are delayed. We suggest that somatic MNs and OLPs are generated sequentially from a common set of MN-OL precursors whose position in the VZ is influenced by Pax6. Neuron-glia fate switching might be a preprogrammed property of these precursors or a response to feedback from newly generated neurons. OLs developed normally in explants of Isl1(-/-) spinal cords, which lack MNs, arguing against feedback control and suggesting that the neuron-glia switch is an intrinsic developmental program in a specific subset of neural precursors. Copyright 1998 Academic Press. |
