| First Author | Carić D | Year | 1997 |
| Journal | Development | Volume | 124 |
| Issue | 24 | Pages | 5087-96 |
| PubMed ID | 9362466 | Mgi Jnum | J:45299 |
| Mgi Id | MGI:1194985 | Doi | 10.1242/dev.124.24.5087 |
| Citation | Caric D, et al. (1997) Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6. Development 124(24):5087-96 |
| abstractText | The cerebral cortex forms by the orderly migration and subsequent differentiation of neuronal precursors generated in the proliferative ventricular zone. We studied the role of the transcription factor Pax-6, which is expressed in the ventricular zone, in cortical development. Embryos homozygous for a mutation of Pax-6 (Small eye; Sey) had abnormalities suggesting defective migration of late-born cortical precursors. When late-born Sey/Sey precursors were transplanted into wild-type embryonic rat cortex, they showed similar integrative, migrational and differentiative abilities to those of transplanted wild-type mouse precursors. These results suggest that postmitotic cortical cells do not need Pax-6 to acquire the capacity to migrate and differentiate, but that Pax-6 generates a cortical environment that permits later-born precursors to express their full developmental potential. |
