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Publication : The small-eye mutation results in abnormalities in the lateral cortical migratory stream.

First Author  Brunjes PC Year  1998
Journal  Brain Res Dev Brain Res Volume  110
Issue  1 Pages  121-5
PubMed ID  9733944 Mgi Jnum  J:50060
Mgi Id  MGI:1289798 Doi  10.1016/s0165-3806(98)00089-3
Citation  Brunjes PC, et al. (1998) The small-eye mutation results in abnormalities in the lateral cortical migratory stream. Brain Res Dev Brain Res 110(1):121-5
abstractText  Mice with homozygous mutations of the Pax-6 gene exhibit a constellation of developmental problems including the absence of eyes and nasal cavities and problems in the movement of neuroblasts out of the germinal epithelium. In this paper, we demonstrate further disturbances in neuronal migration. Normally, cells produced along the lateral ventricles move laterally across the pallium, ultimately coming to reside in the lateral neocortex and primary olfactory cortex. In mutant animals, these cells continue to migrate to the pial surface of the brain. Copyright 1998 Elsevier Science B. V.
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