| First Author | Huseby ES | Year | 2001 |
| Journal | J Exp Med | Volume | 194 |
| Issue | 5 | Pages | 669-76 |
| PubMed ID | 11535634 | Mgi Jnum | J:118575 |
| Mgi Id | MGI:3699788 | Doi | 10.1084/jem.194.5.669 |
| Citation | Huseby ES, et al. (2001) A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple sclerosis. J Exp Med 194(5):669-76 |
| abstractText | Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4(+) and CD8(+) T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4(+) myelin-specific T cells. The role of CD8(+) myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8(+) T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8(+) T cell-mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4(+) T cell-mediated EAE. These data suggest that myelin-specific CD8(+) T cells could function as effector cells in the pathogenesis of MS. |
