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Publication : Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin.

First Author  Snaidero N Year  2017
Journal  Cell Rep Volume  18
Issue  2 Pages  314-323
PubMed ID  28076777 Mgi Jnum  J:251607
Mgi Id  MGI:6102993 Doi  10.1016/j.celrep.2016.12.053
Citation  Snaidero N, et al. (2017) Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin. Cell Rep 18(2):314-323
abstractText  The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with the underlying axon. To be functionally connected to the neuron, oligodendrocytes maintain non-compacted myelin as cytoplasmic nanochannels. Here, we used high-pressure freezing for electron microscopy to study these cytoplasmic regions within myelin close to their native state. We identified 2,''3''-cyclic nucleotide 3''-phosphodiesterase (CNP), an oligodendrocyte-specific protein previously implicated in the maintenance of axonal integrity, as an essential factor in generating and maintaining cytoplasm within the myelin compartment. We provide evidence that CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP). Our study provides a molecular and structural framework for understanding how myelin maintains its cytoplasm to function as an active axon-glial unit.
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