| First Author | Beechey CV | Year | 1985 |
| Journal | Mouse News Lett | Volume | 73 |
| Pages | 17 | Mgi Jnum | J:14014 |
| Mgi Id | MGI:62192 | Citation | Beechey CV, et al. (1985) Male-fertile black-eyed white at Sl locus. Mouse News Lett 73:17 |
| abstractText | Full text of MNL contribution: New mutants: Male-fertile black-eyed white a t S1 locus. Four steel mutants, Sl<8H>, Sl<9H>, SI<1OH> and Sl<1lH>, have been recovered in a specific locus experiment in which (C3H x 101)F>1< males were X-irradiated with 5 Gy + 5 Gy (24 h interval) and mated to tester stock females homozygous for a bp, d se and ru ep, with spermatogonial sampling. Heterozygotes for each allele are very similar, with lighter coat and feet, occasional white head-dot and sometimes a white end to the tail. The effect is slightest in Sl<11H>, which was originally kept mainly because of the small size of the propositus. With Sl<con>, all alleles give mice with very light coats which are fertile in the male but sterile in the female, with very small ovaries. Homozygotes are anaemic prenatal lethals in Sl<8H> and anaemic neonatal ones in Sl<9H> and Sl<10H>. In Sl<11H>, however, they survive to become black-eyed whites, with pigmented ears and scrotum. These are fertile in the male and sterile (with very small ovaries) in the female. In this respect they resemble contrasted (Sl<con>) but the homozygous effect on pigmentation is muoh more severe. A fifth steeloid phenotype in the same experiment seems to be always associated with a reciprocal translocation, as shown by semi-sterility of carriers and presence of a quadrivalent at metaphase I. Thus it resembles the Sl locus translocations described by Cacheiro and Russell (Genet. Res. 25: 193-195, 1975) but present evidence suggests that the Sl locus is not involved, since it does not give a very light-coated phenotype with Sl<con>. (Beechey and Searle) |
