| First Author | Steel KP | Year | 1992 |
| Journal | Development | Volume | 115 |
| Issue | 4 | Pages | 1111-9 |
| PubMed ID | 1280558 | Mgi Jnum | J:31646 |
| Mgi Id | MGI:79132 | Doi | 10.1242/dev.115.4.1111 |
| Citation | Steel KP, et al. (1992) TRP-2/DT, a new early melanoblast marker, shows that steel growth factor (c-kit ligand) is a survival factor. Development 115(4):1111-9 |
| abstractText | We have used a probe derived from TRP-2/DT to detect migratory melanoblasts shortly after they emerge from the neural crest, as early as 10 days post coitum (dpc). TRP-2/DT expression is otherwise restricted to the presumptive pigmented retinal epithelium, the developing telencephalon and the endolymphatic duct. The pattern of steel and c-kit hybridisation in the developing brain differed from that of TRP-2. TRP-1 and tyrosinase probes also detected melanoblasts but were both expressed later in development than TRP-2. We used the TRP-2/DT probe to investigate the way that the Steel-dickie (Sld) mutation interferes with melanocyte development, and found that the membrane-bound steel growth factor which is missing in Sld/Sld mutants is necessary for the survival of melanoblasts but not for their early migration and initial differentiation. |
