| First Author | Rhodes R | Year | 1994 |
| Journal | Mouse Genome | Volume | 92 |
| Issue | 2 | Pages | 355 |
| Mgi Jnum | J:19230 | Mgi Id | MGI:67420 |
| Citation | Rhodes R (1994) Remutation at limb deformity locus. Mouse Genome 92(2):355 |
| abstractText | Full text of Mouse Genome contribution: Research News: 6. Remutation at limb deformity locus. A remutation to limb deformity (ld) on Chromosome 2 occurred spontaneously at The Jackson Laboratory in the B10.M-H2f/nMob (also known as B10.M/n) strain in December of 1992. Three males were born in a litter of seven with short front and hind legs and deformed feet. The mutation is recessive and homozygotes of both sexes are viable and fertile. One of the mutants was outcrossed to CAST/Ei females to produce the F2 generation for genetic mapping. When tissues were taken from F2 progeny carrying the mutation, it was found that some of the animals only had one kidney, a feature of some limb deformity mutants. After it was determined that the mutation was on Chromosome 2, an allele test with limb deformity was done. A female homozygous for the new mutation was mated to a male from the LDJ/Le stock that was ldJ +/+ mg, This mating produced a litter of 5 in which 3 mice were affected and a second litter of 9 in which 4 mice were affected, as expected if the mutations were allelic. Therefore the deviant carries a remutation of limb deformity that has been designated ld2J. Embryos will be cryopreserved and DNA will be available from The Jackson Laboratory DNA Resource. (R. Rhodes) |
