| First Author | Campagnolo L | Year | 2008 |
| Journal | Gene Expr Patterns | Volume | 8 |
| Issue | 6 | Pages | 389-96 |
| PubMed ID | 18556249 | Mgi Jnum | J:137617 |
| Mgi Id | MGI:3801358 | Doi | 10.1016/j.gep.2008.05.001 |
| Citation | Campagnolo L, et al. (2008) Expression of EGFL7 in primordial germ cells and in adult ovaries and testes. Gene Expr Patterns 8(6):389-96 |
| abstractText | We have previously reported the isolation and characterization of a novel endothelial-restricted gene, Egfl7, that encodes a secreted protein of about 30-kDa. We and others demonstrated that Egfl7 is highly expressed by endothelial cells during embryonic development and becomes down-regulated in the adult vasculature. In the present paper, we show that during mouse embryonic development, Egfl7 is also expressed by primordial germ cells (PGC). Expression is down-regulated when PGCs differentiate into pro-spermatogonia and oogonia, and by 15.5dpc Egfl7 can no longer be detected in the germ line of both sexes. Notably, Egfl7 is again transiently up-regulated in germ cells of the adult testis. In contrast, expression in the ovary remains limited to the vascular endothelium. Our results provide the first evidence of a non-endothelial expression of EGFL7 and suggest distinctive roles for Egfl7 in vascular development and germ cell differentiation. |
