| First Author | Sawada K | Year | 1991 |
| Journal | J Reprod Fertil | Volume | 93 |
| Issue | 2 | Pages | 287-94 |
| PubMed ID | 1686280 | Mgi Jnum | J:1856 |
| Mgi Id | MGI:50380 | Doi | 10.1530/jrf.0.0930287 |
| Citation | Sawada K, et al. (1991) Effect of the W mutation, for white belly spot, on testicular germ cell differentiation in mice. J Reprod Fertil 93(2):287-94 |
| abstractText | The effect of the mutation for white belly spot controlled by the dominant gene W on spermatogenesis in mice was examined by experimental cryptorchidism and its surgical reversal. The course of spermatogenesis from spermatogonia to spermatid was normal in intact testes of W/+ mice. In cryptorchid testes, there was no difference in the number and activity of Type A spermatogonia between the testes of W/+ and +/+ mice, in mitotic and labelling indices. Although surgical reversal of the cryptorchid testis resulted in regenerative differentiation of germ cells in both genotypes, the recovery of cell differentiation in the W/+ testis was slower than in the +/+ testis. There were fewer germ cells, such as intermediate-Type B spermatogonia or more advanced ones, in W/+ testes. On Day 17 after surgical reversal, cell associations in W/+ testes were abnormal and the numbers of intermediate-Type B spermatogonia, spermatocytes and spermatids were approximately 70, 50 and 15%, respectively, of those in +/+ testes. These results indicate that the W gene affects spermatogenic cell differentiation in adult mice. |
