| First Author | Aibara D | Year | 2018 |
| Journal | Mol Cell Endocrinol | Volume | 474 |
| Pages | 48-56 | PubMed ID | 29454584 |
| Mgi Jnum | J:265946 | Mgi Id | MGI:6206894 |
| Doi | 10.1016/j.mce.2018.02.006 | Citation | Aibara D, et al. (2018) Fat-specific protein 27 is a novel target gene of liver X receptor alpha. Mol Cell Endocrinol 474:48-56 |
| abstractText | Fat-specific protein 27 (FSP27) is highly expressed in the fatty liver of genetically obese ob/ob mice and promotes hepatic triglyceride (TG) accumulation. The nuclear hormone receptor liver X receptor alpha (LXRalpha) also plays a critical role in the control of TG levels in the liver. The present study demonstrated transcriptional regulation of Fsp27a and Fsp27b genes by LXRalpha. Treatment with the LXR ligand T0901317 markedly increased Fsp27a and Fsp27b mRNAs in wild-type C57BL/6J and ob/ob mouse livers. A reporter assay indicated that two LXR-responsive elements (LXREs) are necessary for LXRalpha-dependent induction of Fsp27a and Fsp27b promoter activities. Furthermore, the LXRalpha/retinoid X receptor alpha complex is capable of directly binding to the two LXREs both in vitro and in vivo. These results suggest that LXRalpha positively regulates Fsp27a and Fsp27b expression through two functional LXREs. Fsp27a/b are novel LXR target genes in the ob/ob fatty liver. |
