| First Author | Breslow MJ | Year | 1997 |
| Journal | Life Sci | Volume | 61 |
| Issue | 1 | Pages | 59-64 |
| PubMed ID | 9200670 | Mgi Jnum | J:41326 |
| Mgi Id | MGI:893751 | Doi | 10.1016/s0024-3205(97)00358-5 |
| Citation | Breslow MJ, et al. (1997) Beta-3 adrenoceptor (beta-3AR) expression in leptin treated OB/OB mice. Life Sci 61(1):59-64 |
| abstractText | Leptin-deficient Ob/Ob mice are hypometabolic and have reduced fat cell expression of beta-3 adrenoceptors (ARs). To determine whether leptin repletion restores beta-3 AR number, C57BL/6J Ob/Ob mice were given exogenous leptin (5 mg/kg IP daily) for 21 days. Leptin administration reduced body weight from 43.1+/-3.7 to 34.1+/-3.7 g in Ob/Ob animals but had no effect on weight in wildtype animals. Body weight increased by 12% in Ob/Ob mice receiving saline. Beta-3 AR mRNA concentrations were markedly reduced in Ob/Ob animals at baseline. Leptin increased beta-3 AR mRNA to control levels in Ob/Ob mice, but had no effect in wildtype animals. Adipocyte leptin mRNA was increased by 400% in Ob/Ob mice and did not suppress with exogenous leptin administration, suggesting no direct feedback regulation of leptin synthesis. We speculate that restoration of beta-3 AR expression by repleting leptin may be important in correcting hypometabolism in Ob/Ob animals. |
